'Serious blow' for England as Atkinson is forced off due to a hamstring issue.
The pace bowler added to the injury concerns plaguing England after leaving the ground on the second morning of the Boxing Day Test in the Ashes series.
Atkinson felt a problem in his hamstring immediately following a delivery of the fourth over on Saturday.
The touring camp stated the 27-year-old had experienced "tightness" and would spend time off the field to undergo evaluation "during the day".
The concluding match in this Ashes battle in Sydney starts at the end of the week.
England have already lost key quicks one seamer to a knee injury and Jofra Archer with an abdominal strain on this Ashes tour.
A replacement bowler was called up to provide backup.
His form was underwhelming during the first two matches, managing only a handful of scalps.
He was left out from the previous Test, before being recalled for the Boxing Day match to fill the void.
Atkinson showed better form in Melbourne, claiming a couple of wickets during the host's first knock, then making 28 with the bat among just a trio of English batsmen to reach double figures.
Post a single over in Australia's second innings, he resumed on Saturday morning and dismissed the nightwatchman Scott Boland caught behind.
Unfortunately, towards the conclusion of the fifth over, he sent down a variation to Travis Head and suddenly grabbed for his hamstring.
Atkinson returned to the side for the fourth Ashes Test following his omission of the third.
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